Ankylosing spondylitis, also known as Bechterew’s disease, is a chronic inflammatory condition that affects the spine and sacroiliac joints. Over time, it can limit mobility and significantly affect quality of life. In modern medical literature, the term ankylosing spondylitis is used more often, while the name Bechterew’s disease is gradually becoming less common. In the early stages, the condition is often mistaken for overuse, degenerative spinal changes, or ordinary back pain.
Below, we explain how the disease develops, its early symptoms, diagnostic methods, treatment options, and the warning signs that should not be ignored.
Ankylosing spondylitis is a systemic rheumatological disease that belongs to the group of axial spondyloarthritis conditions. In international practice, the term ankylosing spondylitis is commonly used, while the broader modern term is axial spondyloarthritis.
The inflammatory process usually begins in the sacroiliac joints, where the pelvis connects to the lower spine. It may then spread to the intervertebral joints, ligaments, and the areas where tendons attach to bone.
In ankylosing spondylitis, the immune system maintains chronic inflammation. This leads to pain, stiffness, reduced spinal mobility, and, over time, the formation of bony bridges between the vertebrae.
There is no single everyday cause of ankylosing spondylitis. The condition develops gradually and is associated with several risk factors, including:
HLA-B27 is an important genetic marker, but its presence does not confirm the diagnosis. Some people carry this marker and never develop the disease. For this reason, diagnosis is based on a combination of symptoms, physical examination findings, and diagnostic imaging.

The symptoms of ankylosing spondylitis usually develop gradually. A person may live with lower back pain for months and attribute it to sedentary work, sports, or fatigue while the inflammatory process continues.
A typical early sign is back pain lasting longer than three months. It becomes worse at night, may wake the person in the early morning, is accompanied by morning stiffness, and improves after movement.
Inflammatory back pain has several characteristic features:
If back pain and discomfort improve with movement rather than lying down, the condition is less likely to be caused by ordinary mechanical strain.
The main symptoms are associated with the spine, joints, and the areas where ligaments and tendons attach to bone. Some patients also develop symptoms outside the joints, which are important for diagnosis.
The most common signs include:
A separate warning sign is sudden redness of the eye accompanied by pain and sensitivity to light. This may indicate uveitis, which is often associated with spondyloarthritis and requires urgent examination by an ophthalmologist.
The course of the disease depends on the activity of inflammation, how quickly the diagnosis is established, the effectiveness of treatment, and lifestyle factors. Without proper control, the disease may gradually progress from functional pain to permanent structural changes.
Several stages can be distinguished:
In the later stages, a person may lose the ability to bend normally, rotate the torso, or fully expand the chest. For this reason, early diagnosis is essential for preserving mobility in the future.
Ankylosing spondylitis most commonly affects the sacroiliac joints, lumbar spine, thoracic spine, and cervical region. The inflammation spreads along the axis of the body, which is why the condition is described as axial.
Over time, structures other than the joints may also be affected. These include ligaments, joint capsules, intervertebral connections, and entheses, where tendons and ligaments attach to bone.
Peripheral symptoms are also important. In some patients, joint pain appears before back pain or develops at the same time. Inflammation of large joints can significantly reduce the ability to walk, work, and tolerate physical activity.
Diagnosis requires a comprehensive approach. It is based on symptoms, physical examination, laboratory results, and diagnostic imaging.
During the examination, the doctor assesses:
Functional tests may be used to assess mobility, including:
These tests show how the disease affects the body in practice and help determine the next steps in treatment.
Laboratory tests help assess inflammatory activity and rule out other causes of pain. Basic tests may include:
Normal C-reactive protein or erythrocyte sedimentation rate results do not rule out the diagnosis. In ankylosing spondylitis, structural changes may be visible on X-ray, while active inflammation may be detected with MRI.
Diagnostic imaging may include:
Modern medicine cannot completely cure ankylosing spondylitis. However, appropriate treatment can reduce pain, suppress inflammation, preserve mobility, and lower the risk of severe vertebral fusion.
The main treatment approaches include:
Medication treatment must be selected by a rheumatologist. Changing medications without medical supervision, interrupting biological therapy, or taking nonsteroidal anti-inflammatory medications for prolonged periods without monitoring can increase risks to the stomach, kidneys, cardiovascular system, and overall disease control.
Movement is an important part of treatment for ankylosing spondylitis. Rest does not relieve inflammatory back pain, while prolonged inactivity accelerates the loss of mobility.
The most beneficial activities include:
Physical activity should be increased gradually and adapted to the patient’s condition. It is best to exercise under the supervision of a rehabilitation specialist and follow an individualized program.
During an active flare-up, the exercise plan may need to be adjusted. During stable periods, the load can be increased gradually to maintain muscle strength, breathing function, and spinal mobility.
The prognosis of ankylosing spondylitis depends directly on how early the diagnosis is established and how effectively inflammation is controlled. A person who starts treatment in the early stages has a much better chance of maintaining normal posture and mobility.
Without treatment, the disease can lead to persistent pain, loss of mobility, ankylosis, spinal deformity, and an increased risk of fractures after a fall. A fused spine becomes less flexible and is more vulnerable to injury.
Possible complications include:
You should see a doctor if back pain lasts longer than three months, becomes worse at night, is accompanied by morning stiffness, or improves after movement.
In ankylosing spondylitis, early medical evaluation is the most effective way to control pain, preserve mobility, and maintain quality of life.
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